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Synthesis of Hydrophilic Polymeric Supports with Poly-HIPE Structures Based on Acrylates for Pharmaceutical Applications AITranslate

Giulia De Soricellis; Francesca Rinaldi; Sara Tengattini; Caterina Temporini; Gabriella Massolini; Delia Mandracchia; Chiara Milanese; Fiorenzo Casero; Enrica Calleri
University of Pavia; University of Pavia; University of Pavia; University of Pavia; University of Pavia; University of Brescia; University of Pavia; University of Pavia; University of Pavia
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Abstract AITranslate

In the present paper, the synthesis and characterization of a hydrophilic acrylate-based poly-HIPE for pharmaceutical applications have been reported and discussed with particular emphasis on the effect of curing over morphology. According to previously described experimental setups and procedures, photoinduced polymerization has been successfully achieved, exposing the emulsion to UV light for 15, 30, and 60 min. Polymeric monoliths were fully investigated in terms of morphology, calorimetric analysis (TGA and DSC), FTIR, porosity (BET), and gel content analysis. The results highlighted an increase in the specific surface area as the curing time is prolonged, therefore, affecting the morphology. The material has found application as support for in-flow experiments to evaluate the adsorption of molecules of pharmaceutical interest (small-molecule drugs and monoclonal antibodies). The versatility of poly-HIPEs and their potential in bioreactor application was discussed.

KeyWords AITranslate

polyHIPEs hydrophilic polymers acrylates porosity monoclonal antibodies drugs
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Basic Information:

DOI：https://doi.org/10.1021/acsapm.2c02115

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Citation Information:

In the present paper, the synthesis and characterization of a hydrophilic acrylate-based poly-HIPE for pharmaceutical applications have been reported and discussed with particular emphasis on the effect of curing over morphology. According to previously described experimental setups and procedures, photoinduced polymerization has been successfully achieved, exposing the emulsion to UV light for 15, 30, and 60 min. Polymeric monoliths were fully investigated in terms of morphology, calorimetric analysis (TGA and DSC), FTIR, porosity (BET), and gel content analysis. The results highlighted an increase in the specific surface area as the curing time is prolonged, therefore, affecting the morphology. The material has found application as support for in-flow experiments to evaluate the adsorption of molecules of pharmaceutical interest (small-molecule drugs and monoclonal antibodies). The versatility of poly-HIPEs and their potential in bioreactor application was discussed.

quote

GB/T 7714-2015 [1] Giulia De Soricellis, Francesca Rinaldi, Sara Tengattini, et al. ACS Applied Polymer Materials, 2023(5). DOI:10.1021/acsapm.2c02115.
MLA [1] Giulia De Soricellis, et al., ACS Applied Polymer Materials, no. 5, 2023, https://doi.org/10.1021/acsapm.2c02115.
APA [1] Giulia De Soricellis, Francesca Rinaldi, Sara Tengattini, Caterina Temporini, Gabriella Massolini, Delia Mandracchia, Chiara Milanese, Fiorenzo Casero, & Enrica Calleri. (2023). ACS Applied Polymer Materials(5). https://doi.org/10.1021/acsapm.2c02115
IEEE [1] Giulia De Soricellis, Francesca Rinaldi, Sara Tengattini, Caterina Temporini, Gabriella Massolini, Delia Mandracchia, Chiara Milanese, Fiorenzo Casero, and Enrica Calleri, ACS Applied Polymer Materials, no. 5, 2023, doi: 10.1021/acsapm.2c02115. keywords: {polyHIPEs;hydrophilic polymers;acrylates;porosity;monoclonal antibodies;drugs}