Well ordered-microstructure bioceramics AITranslate

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DOI：https://doi.org/10.1016/j.apmt.2021.101194

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It is a great challenge to endow the bioceramics with the bone-matched mechanical performances. Here, capturing inspiration from well ordered-microstructures in the high-performance natural composites, we propose a universal biomineralization-assembly-sintering approach for the fabrication of well ordered-microstructure meta-hydroxyapatite. Owing to the well ordered-microstructure and a new metal ions-related interface toughening mechanism, this well ordered-microstructure hydroxyapatite exhibits remarkable mechanical performances, which are far beyond those of existing hydroxyapatite-based bioceramic and totally matched with the human cortical bone. Furthermore, the ordered microstructure plays a significant role in modulating the cell fates and finally stimulating bone defects regeneration in vivo. This work not only provides a strategy for the fabrication of well ordered-microstructure bioceramic but also broadens the horizons for the interface toughening mechanism of composites and microstructure design of biomaterials for bone regeneration. Graphical abstract Download : Download high-res image (200KB) Download : Download full-size image Well ordered-microstructure bioceramics are fabricated through a universal approach of biomineralization-assembly-sintering. The prepared well-ordered biomaterials exhibit superior mechanical performances due to the well-ordered microstructure and the novel interface toughening mechanism. In addition, it is also found that this well-ordered microstructure is important for modulating the cell fates and accelerating the bone regeneration in vivo.