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Sustainable amorphous Fenton nanosystem for visualization-guided synergistic tumor elimination AITranslate

Jingjing Wang; Wei Zhang; ShiYu Lu; Wei Tang; Jie Hu; Wenting Yang; Qiuye Zhang; Xingyue Wang; Jun Deng; Yang Cao; Hui Liu;
Peking University; Chongqing Medical University; Peking University; Southwest University; Southwest University; Southwest University; Southwest University; Chongqing Medical University; Army Medical University (Third Military Medical University); Chongqing Medical University; Southwest University
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Publisher: Elsevier
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Abstract AITranslate

Chemodynamic therapy (CDT) shows great potential in tumor treatment, in which tumor cells are killed by hydroxyl radicals (·OH) generated by Fenton-catalysis-mediated hydrogen peroxide (H2O2) disproportionation. Fabricating a high-performance tumor microenvironment (TME)-responsive Fenton nanocatalyst and realizing sustainable ·OH production are essential for effective tumor elimination but still challenging. Herein, we reported a sustainable amorphous Fenton nanosystem (SAFN) for visualization-guided synergistic tumor therapy, highlighting the superiority of cascade catalysis and the sustainability of the Fenton nanosystem. The SAFN was fabricated by rational integration of a polydopamine (PDA) core, an amorphous ferric phosphate (FePi) payload, glucose oxidase (GOx) decoration, and a bull serum albumin coating. In an acidic TME, Fe(III) ions were released on demand from FePi and reduced to high-activity Fe(II) by PDA. The reducing capacity of PDA was stronger under acidic conditions, due to C=O exposure. Fe(II) and H2O2 are sustainably supplied by the PDA-reducing and GOx catalytic chemistry, achieving long-lasting ·OH production for enhanced CDT (ECDT). Localized hyperthermia can be generated by PDA under near-infrared laser irradiation for low-temperature photothermal therapy (LT-PTT) in a GOx-induced energy-shortage TME. In addition, a remarkable antitumor effect is achieved by this sustainable nanosystem through the synergistic effect of the starvation/LT-PTT/ECDT strategy. Graphical abstract A sustainable amorphous Fenton nanosystem is constructed based on polydopamine, amorphous ferric phosphate, and glucose oxidase. Fenton catalyst Fe(II) and substrate H2O2 are sustainably supplied by the polydopamine-reducing and glucose oxidase catalytic chemistry, achieving long-lasting ·OH production. Tumor cells can be eliminated by the synergistic effect of starvation/photothermal/chemodynamic therapy. Download : Download high-res image (204KB) Download : Download full-size image

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DOI：https://doi.org/10.1016/j.apmt.2021.101189

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Chemodynamic therapy (CDT) shows great potential in tumor treatment, in which tumor cells are killed by hydroxyl radicals (·OH) generated by Fenton-catalysis-mediated hydrogen peroxide (H2O2) disproportionation. Fabricating a high-performance tumor microenvironment (TME)-responsive Fenton nanocatalyst and realizing sustainable ·OH production are essential for effective tumor elimination but still challenging. Herein, we reported a sustainable amorphous Fenton nanosystem (SAFN) for visualization-guided synergistic tumor therapy, highlighting the superiority of cascade catalysis and the sustainability of the Fenton nanosystem. The SAFN was fabricated by rational integration of a polydopamine (PDA) core, an amorphous ferric phosphate (FePi) payload, glucose oxidase (GOx) decoration, and a bull serum albumin coating. In an acidic TME, Fe(III) ions were released on demand from FePi and reduced to high-activity Fe(II) by PDA. The reducing capacity of PDA was stronger under acidic conditions, due to C=O exposure. Fe(II) and H2O2 are sustainably supplied by the PDA-reducing and GOx catalytic chemistry, achieving long-lasting ·OH production for enhanced CDT (ECDT). Localized hyperthermia can be generated by PDA under near-infrared laser irradiation for low-temperature photothermal therapy (LT-PTT) in a GOx-induced energy-shortage TME. In addition, a remarkable antitumor effect is achieved by this sustainable nanosystem through the synergistic effect of the starvation/LT-PTT/ECDT strategy. Graphical abstract A sustainable amorphous Fenton nanosystem is constructed based on polydopamine, amorphous ferric phosphate, and glucose oxidase. Fenton catalyst Fe(II) and substrate H2O2 are sustainably supplied by the polydopamine-reducing and glucose oxidase catalytic chemistry, achieving long-lasting ·OH production. Tumor cells can be eliminated by the synergistic effect of starvation/photothermal/chemodynamic therapy. Download : Download high-res image (204KB) Download : Download full-size image

quote

GB/T 7714-2015 [1] Jingjing Wang, Wei Zhang, ShiYu Lu, et al. Applied Materials Today, 2021(25). DOI:10.1016/j.apmt.2021.101189.
MLA [1] Jingjing Wang, et al., Applied Materials Today, no. 25, 2021, https://doi.org/10.1016/j.apmt.2021.101189.
APA [1] Jingjing Wang, Wei Zhang, ShiYu Lu, Wei Tang, Jie Hu, Wenting Yang, Qiuye Zhang, Xingyue Wang, Jun Deng, Yang Cao, & Hui Liu. (2021). Applied Materials Today(25). https://doi.org/10.1016/j.apmt.2021.101189
IEEE [1] Jingjing Wang, Wei Zhang, ShiYu Lu, Wei Tang, Jie Hu, Wenting Yang, Qiuye Zhang, Xingyue Wang, Jun Deng, Yang Cao, and Hui Liu, Applied Materials Today, no. 25, 2021, doi: 10.1016/j.apmt.2021.101189.