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Gelatin-Coated Copper-Based Metal–Organic Framework for Controlled Insulin Delivery: Possibility toward Oral Delivery System AITranslate

Pawan Kumar; Navpreet Kaur; Pranav Tiwari; Anoop Kumar Gupta; Shaikh M. Mobin
Indian Institute of Technology; Indian Institute of Technology Indore; Indian Institute of Technology; Pandit Prithi Nath College (C. S. J. M. University); Indian Institute of Technology Indore
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Publisher: ACS
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Abstract AITranslate

The development of nontoxic, hemocompatible materials for controlled insulin delivery is a great challenging task for researchers. Herein, we demonstrate the design of a novel linker 5,5′-((pyridine-2,6-diylbis(methylene)) bis(oxy))diisophthalic acid (H4L) and its utilization to synthesize a new Cu-MOF (IITI-3). IITI-3 crystallizes in a tetragonal crystal system with space group I4/mmm and shows a high Brunauer–Emmett–Teller (BET) surface area of 1026.5 m2/g with pore diameter (Barrett–Joyner–Halenda pore size distribution) of 3.413 nm. The IITI-3 is found to be stable in the biological fluid pH ranges from 3 to 10. Moreover, IITI-3 were explored for insulin delivery by coating the IITI-3 with gelatin (gel@insIITI-3); the overall insulin was controlled from the framework. The obtained result paves a new avenue for the oral delivery of insulin using the IITI-3 metal-organic framework.

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DOI：https://doi.org/10.1021/acsmaterialslett.2c01175

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Citation Information:

The development of nontoxic, hemocompatible materials for controlled insulin delivery is a great challenging task for researchers. Herein, we demonstrate the design of a novel linker 5,5′-((pyridine-2,6-diylbis(methylene)) bis(oxy))diisophthalic acid (H4L) and its utilization to synthesize a new Cu-MOF (IITI-3). IITI-3 crystallizes in a tetragonal crystal system with space group I4/mmm and shows a high Brunauer–Emmett–Teller (BET) surface area of 1026.5 m2/g with pore diameter (Barrett–Joyner–Halenda pore size distribution) of 3.413 nm. The IITI-3 is found to be stable in the biological fluid pH ranges from 3 to 10. Moreover, IITI-3 were explored for insulin delivery by coating the IITI-3 with gelatin (gel@insIITI-3); the overall insulin was controlled from the framework. The obtained result paves a new avenue for the oral delivery of insulin using the IITI-3 metal-organic framework.

quote

GB/T 7714-2015 [1] Pawan Kumar, Navpreet Kaur, Pranav Tiwari, et al. ACS Materials Letters, 2023(5). DOI:10.1021/acsmaterialslett.2c01175.
MLA [1] Pawan Kumar, et al., ACS Materials Letters, no. 5, 2023, https://doi.org/10.1021/acsmaterialslett.2c01175.
APA [1] Pawan Kumar, Navpreet Kaur, Pranav Tiwari, Anoop Kumar Gupta, & Shaikh M. Mobin. (2023). ACS Materials Letters(5). https://doi.org/10.1021/acsmaterialslett.2c01175
IEEE [1] Pawan Kumar, Navpreet Kaur, Pranav Tiwari, Anoop Kumar Gupta, and Shaikh M. Mobin, ACS Materials Letters, no. 5, 2023, doi: 10.1021/acsmaterialslett.2c01175.