daohang fenxiangbox searchbox qikanlogonew daohangnew searchboxnew navrightzone footerzone paper
English
Chinese 简体中文 English English
Home > Journals > ACS Applied Polymer Materials
Next Article ›

Polymeric Iron Chelator with Enhanced Iron Affinity as a Broad-Spectrum Antifungal Agent AITranslate

Jian Qian; Nathan P. Wiederhold; Thomas Patterson; Hoja Patterson; Cory J. Berkland
The University of Kansas; The University of Texas Health Science Center at San Antonio; The University of Texas Health Science Center at San Antonio; The University of Texas Health Science Center at San Antonio; The University of Kansas
AITranslate
Publisher: ACS
Share Citation Information Add to Favorites

    Scan to share on WeChat or Moments

Use WeChat scan.
Share with WeChat friends or Moments

Abstract AITranslate

Developing broad-spectrum antifungal drugs represents a pressing need for reducing the global burden of fungal infections. We took advantage of the conformational stability effect to develop a high-avidity polymeric iron chelator, 2,3-dihydroxybenzoic acid-conjugated poly(l-lysine hydrochloride) (PLL-DHBA), which exhibited a stronger iron affinity than typical siderophores produced by fungi. Minimum inhibitory concentration studies against 8 types of fungi including 37 strains showed that the PLL-DHBA iron chelator exhibited a broad-spectrum antifungal effect. Moreover, PLL-DHBA was even more potent than some traditional antifungal drugs for certain drug-resistant fungi.

KeyWords AITranslate

antifungal drug polymeric iron chelator broadspectrum antifungal effect siderophore reductive iron assimilation
No data

Basic Information:

DOI：https://doi.org/10.1021/acsapm.1c01269

Chinese Library Classification Number:

Citation Information:

Developing broad-spectrum antifungal drugs represents a pressing need for reducing the global burden of fungal infections. We took advantage of the conformational stability effect to develop a high-avidity polymeric iron chelator, 2,3-dihydroxybenzoic acid-conjugated poly(l-lysine hydrochloride) (PLL-DHBA), which exhibited a stronger iron affinity than typical siderophores produced by fungi. Minimum inhibitory concentration studies against 8 types of fungi including 37 strains showed that the PLL-DHBA iron chelator exhibited a broad-spectrum antifungal effect. Moreover, PLL-DHBA was even more potent than some traditional antifungal drugs for certain drug-resistant fungi.

quote

GB/T 7714-2015 [1] Jian Qian, Nathan P. Wiederhold, Thomas Patterson, et al. ACS Applied Polymer Materials, 2021(3). DOI:10.1021/acsapm.1c01269.
MLA [1] Jian Qian, et al., ACS Applied Polymer Materials, no. 3, 2021, https://doi.org/10.1021/acsapm.1c01269.
APA [1] Jian Qian, Nathan P. Wiederhold, Thomas Patterson, Hoja Patterson, & Cory J. Berkland. (2021). ACS Applied Polymer Materials(3). https://doi.org/10.1021/acsapm.1c01269
IEEE [1] Jian Qian, Nathan P. Wiederhold, Thomas Patterson, Hoja Patterson, and Cory J. Berkland, ACS Applied Polymer Materials, no. 3, 2021, doi: 10.1021/acsapm.1c01269. keywords: {antifungal drug;polymeric iron chelator;broadspectrum antifungal effect;siderophore;reductive iron assimilation}