Emulsion Template Fabrication of Antibacterial Gelatin-Based Scaffolds with a Preferred Microstructure for Accelerated Wound Healing AITranslate

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DOI：https://doi.org/10.1021/acsapm.2c00350

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Rapid wound healing and antimicrobial therapy have long been considered in wound repair. In this study, gelatin-based scaffolds with a preferred microstructure and antibacterial activity were fabricated by the emulsion template method. Gelatin microspheres of suitable size were prepared by emulsification and fixed with genipin. ε-Polylysine was introduced and adsorbed on the microspheres by electrostatic interactions. These microspheres were gathered and tightened by dialdehyde starch to prepare the gelatin-based scaffold. The prepared scaffolds possessed a porous and interconnected microstructure with the preferred pore sizes of ∼65 μm, which are conducive to skin regeneration. Moreover, the scaffolds showed good mechanical properties and swelling capacity, promising degradability, and good blood compatibility and cytocompatibility. The introduction of ε-polylysine endowed the scaffolds with good tissue adhesiveness and antibacterial activity. As expected, the prepared gelatin-based scaffolds with a preferred microstructure can facilitate the adhesion of more fibroblast cells. The gelatin-based scaffolds showed potential application as antibacterial wound dressings.