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Ultraviolet Light- or pH-Triggered Nitric Oxide Release from a Water-Soluble Polymeric Scaffold AITranslate

Soumya Paul; Swagata Pan; Ayan Chakraborty; Priyadarsi De; Arindam Mukherjee
Indian Institute of Science Education and Research Kolkata; Indian Institute of Science Education and Research Kolkata; Indian Institute of Science Education and Research Kolkata; Indian Institute of Science Education and Research Kolkata; Indian Institute of Science Education and Research Kolkata
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Publisher: ACS
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Abstract AITranslate

To develop nitric oxide (NO)-releasing donors, we synthesized N-nitrosamine-functionalized water-soluble alternating copolymer as a macromolecular scaffold with a high half-life. A reversible addition–fragmentation chain transfer polymerization of maleic anhydride (MA) and styrene (S) using poly(ethylene glycol) methyl ether (mPEG) containing macro-chain transfer agent (mPEG-CDP) (CDP = 4-cyano-(dodecylsulfanylthiocarbonyl)sulfanyl pentanoic acid) produced the mPEG-b-P(MA-alt-S) polymeric scaffold, which was further modified with NO binding motifs. NO detection performed by Griess assay and 1,2-diaminoanthraquinone demonstrated a controlled release of NO from the polymer in acidic pH or with 254 nm UV light.

KeyWords AITranslate

nitric oxide (NO) polymer pH trigger UV trigger Griess assay
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Basic Information:

DOI：https://doi.org/10.1021/acsapm.0c01375

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Citation Information:

To develop nitric oxide (NO)-releasing donors, we synthesized N-nitrosamine-functionalized water-soluble alternating copolymer as a macromolecular scaffold with a high half-life. A reversible addition–fragmentation chain transfer polymerization of maleic anhydride (MA) and styrene (S) using poly(ethylene glycol) methyl ether (mPEG) containing macro-chain transfer agent (mPEG-CDP) (CDP = 4-cyano-(dodecylsulfanylthiocarbonyl)sulfanyl pentanoic acid) produced the mPEG-b-P(MA-alt-S) polymeric scaffold, which was further modified with NO binding motifs. NO detection performed by Griess assay and 1,2-diaminoanthraquinone demonstrated a controlled release of NO from the polymer in acidic pH or with 254 nm UV light.

quote

GB/T 7714-2015 [1] Soumya Paul, Swagata Pan, Ayan Chakraborty, et al. ACS Applied Polymer Materials, 2021(3). DOI:10.1021/acsapm.0c01375.
MLA [1] Soumya Paul, et al., ACS Applied Polymer Materials, no. 3, 2021, https://doi.org/10.1021/acsapm.0c01375.
APA [1] Soumya Paul, Swagata Pan, Ayan Chakraborty, Priyadarsi De, & Arindam Mukherjee. (2021). ACS Applied Polymer Materials(3). https://doi.org/10.1021/acsapm.0c01375
IEEE [1] Soumya Paul, Swagata Pan, Ayan Chakraborty, Priyadarsi De, and Arindam Mukherjee, ACS Applied Polymer Materials, no. 3, 2021, doi: 10.1021/acsapm.0c01375. keywords: {nitric oxide (NO);polymer;pH trigger;UV trigger;Griess assay}