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Drug Interactions with Poly(vinyl chloride) Plasticized with Epoxidized Soybean Oil AITranslate

Hassan Al Salloum; Johanna Saunier; Audrey Da Silva; Katia Manerlax; Lionel Tortolano; Najet Yagoubi;
IFR 141-EA 401−UFR de Pharmacie−Université Paris Sud;IFR 141-EA 401−UFR de Pharmacie−Université Paris Sud;IFR 141-EA 401−UFR de Pharmacie−Université Paris Sud;IFR 141-EA 401−UFR de Pharmacie−Université Paris Sud;IFR 141-EA 401−UFR de Pharmacie−Université Paris Sud;IFR 141-EA 401−UFR de Pharmacie−Université Paris Sud
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Publisher: ACS
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Abstract AITranslate

Plastic infusion tubing is commonly made of plasticized poly(vinyl chloride) (PVC). During infusion, drugs may sorb into the tube influencing the drug amount delivered to the patient and may result in a lower efficiency of the treatment that may compromise the success of the therapy. In this study, the sorption of diazepam from aqueous solutions by PVC-plasticized films was investigated. Epoxidized soybean oil (ESBO)-plasticized films were compared to di-2-ethylhexyl-phthalate (DEHP)- and DEHP/ESBO-plasticized films. ESBO is mainly used as a thermal stabilizer in tubing, but it can be an effective primary and less toxic plasticizer as proven by its use in food packaging. The sorption behavior was different for pure ESBO compared to DEHP and DEHP-based mixtures. This might be interpreted in terms of interaction between the PVC and the plasticizer. The plasticizer’s ability to phase separately above a specific ratio may be a significant parameter.

KeyWords AITranslate

PVC sorption epoxidized soy bean oil DEHP diazepam
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Basic Information:

DOI：https://doi.org/10.1021/acsapm.8b00050

Chinese Library Classification Number:

Citation Information:

Plastic infusion tubing is commonly made of plasticized poly(vinyl chloride) (PVC). During infusion, drugs may sorb into the tube influencing the drug amount delivered to the patient and may result in a lower efficiency of the treatment that may compromise the success of the therapy. In this study, the sorption of diazepam from aqueous solutions by PVC-plasticized films was investigated. Epoxidized soybean oil (ESBO)-plasticized films were compared to di-2-ethylhexyl-phthalate (DEHP)- and DEHP/ESBO-plasticized films. ESBO is mainly used as a thermal stabilizer in tubing, but it can be an effective primary and less toxic plasticizer as proven by its use in food packaging. The sorption behavior was different for pure ESBO compared to DEHP and DEHP-based mixtures. This might be interpreted in terms of interaction between the PVC and the plasticizer. The plasticizer’s ability to phase separately above a specific ratio may be a significant parameter.

quote

GB/T 7714-2015 [1] Hassan Al Salloum, Johanna Saunier, Audrey Da Silva, et al. ACS Applied Polymer Materials, 2019(1). DOI:10.1021/acsapm.8b00050.
MLA [1] Hassan Al Salloum, et al., ACS Applied Polymer Materials, no. 1, 2019, https://doi.org/10.1021/acsapm.8b00050.
APA [1] Hassan Al Salloum, Johanna Saunier, Audrey Da Silva, Katia Manerlax, Lionel Tortolano, & Najet Yagoubi. (2019). ACS Applied Polymer Materials(1). https://doi.org/10.1021/acsapm.8b00050
IEEE [1] Hassan Al Salloum, Johanna Saunier, Audrey Da Silva, Katia Manerlax, Lionel Tortolano, and Najet Yagoubi, ACS Applied Polymer Materials, no. 1, 2019, doi: 10.1021/acsapm.8b00050. keywords: {PVC;sorption;epoxidized soy bean oil;DEHP;diazepam}