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Inhibition of oxidative stress in vivo through enzyme-like activity of carbon dots AITranslate

Chen Dong; Shuna Wang; Menghui Ma; Peifa Wei; Yan Chen; Aiguo Wu; Zhengbao Zha; Hong Bi;
Anhui University; Anhui University; Anhui University; Anhui University; Anhui University; Ningbo Institute of Materials Technology and Engineering; Hefei University of Technology; Anhui University
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Publisher: Elsevier
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Abstract AITranslate

Oxidative stress is a huge challenge to human health, and effective agents for resisting this adverse effect are remains limited recently. Here, an excellent enzyme-like activity of carbon dots (e-CDs) via a facile solvothermal method is reported. In addition, e-CDs exert protective effects in HUVEC cell model by decreasing apoptosis. e-CDs also efficiently diminish ROS and apoptosis damage in mice treated with D-galactose. Furthermore, e-CDs-pretreated mice shows decrease apoptotic proteins in the brain and liver, confirming that e-CDs ameliorate D-galactose induced aging. Compared with general nanozymes, biocompatible e-CDs demonstrate their high potential for anti-aging by the inhibition of oxidative stress. Graphical abstract Download : Download high-res image (138KB) Download : Download full-size image

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DOI：https://doi.org/10.1016/j.apmt.2021.101178

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Citation Information:

Oxidative stress is a huge challenge to human health, and effective agents for resisting this adverse effect are remains limited recently. Here, an excellent enzyme-like activity of carbon dots (e-CDs) via a facile solvothermal method is reported. In addition, e-CDs exert protective effects in HUVEC cell model by decreasing apoptosis. e-CDs also efficiently diminish ROS and apoptosis damage in mice treated with D-galactose. Furthermore, e-CDs-pretreated mice shows decrease apoptotic proteins in the brain and liver, confirming that e-CDs ameliorate D-galactose induced aging. Compared with general nanozymes, biocompatible e-CDs demonstrate their high potential for anti-aging by the inhibition of oxidative stress. Graphical abstract Download : Download high-res image (138KB) Download : Download full-size image

quote

GB/T 7714-2015 [1] Chen Dong, Shuna Wang, Menghui Ma, et al. Applied Materials Today, 2021(25). DOI:10.1016/j.apmt.2021.101178.
MLA [1] Chen Dong, et al., Applied Materials Today, no. 25, 2021, https://doi.org/10.1016/j.apmt.2021.101178.
APA [1] Chen Dong, Shuna Wang, Menghui Ma, Peifa Wei, Yan Chen, Aiguo Wu, Zhengbao Zha, & Hong Bi. (2021). Applied Materials Today(25). https://doi.org/10.1016/j.apmt.2021.101178
IEEE [1] Chen Dong, Shuna Wang, Menghui Ma, Peifa Wei, Yan Chen, Aiguo Wu, Zhengbao Zha, and Hong Bi, Applied Materials Today, no. 25, 2021, doi: 10.1016/j.apmt.2021.101178.