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Macrocycle-Based Polymer Nanocapsules for Hypoxia-Responsive Payload Delivery AITranslate

Chen Sun; Ludan Yue; Qian Cheng; Ziyi Wang; Ruibing Wang;
University of Macau; University of Macau; University of Macau; University of Macau; University of Macau
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Publisher: ACS
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Abstract AITranslate

Hypoxia is a typical hallmark in several disease conditions, particularly in solid tumors. Thus, hypoxia-responsive nanocarriers that may specifically deliver and release payload under hypoxic conditions have been highly sought after, for precision medicine. Herein, we report the first hypoxia-responsive, covalently self-assembled polymer nanocapsules (NCs), formed via directly crosslinking perhydroxycucurbit[6]uril with a ditopic, hypoxia-responsive azobenzene derivative (AZO). Because of the presence of macrocyclic cucurbit[6]uril, the hypoxia-responsive nanocapsules (AZO-NCs) allowed modular, noncovalent surface functionalization. As a proof-of-concept, folate-functionalized AZO-NCs exhibited targeted payload delivery into cancer cells, and more importantly, hypoxia-responsive payload release was validated both in vitro and in vivo.

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DOI：https://doi.org/10.1021/acsmaterialslett.0c00002

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Citation Information:

Hypoxia is a typical hallmark in several disease conditions, particularly in solid tumors. Thus, hypoxia-responsive nanocarriers that may specifically deliver and release payload under hypoxic conditions have been highly sought after, for precision medicine. Herein, we report the first hypoxia-responsive, covalently self-assembled polymer nanocapsules (NCs), formed via directly crosslinking perhydroxycucurbit[6]uril with a ditopic, hypoxia-responsive azobenzene derivative (AZO). Because of the presence of macrocyclic cucurbit[6]uril, the hypoxia-responsive nanocapsules (AZO-NCs) allowed modular, noncovalent surface functionalization. As a proof-of-concept, folate-functionalized AZO-NCs exhibited targeted payload delivery into cancer cells, and more importantly, hypoxia-responsive payload release was validated both in vitro and in vivo.

quote

GB/T 7714-2015 [1] Chen Sun, Ludan Yue, Qian Cheng, et al. ACS Materials Letters, 2020(2). DOI:10.1021/acsmaterialslett.0c00002.
MLA [1] Chen Sun, et al., ACS Materials Letters, no. 2, 2020, https://doi.org/10.1021/acsmaterialslett.0c00002.
APA [1] Chen Sun, Ludan Yue, Qian Cheng, Ziyi Wang, & Ruibing Wang. (2020). ACS Materials Letters(2). https://doi.org/10.1021/acsmaterialslett.0c00002
IEEE [1] Chen Sun, Ludan Yue, Qian Cheng, Ziyi Wang, and Ruibing Wang, ACS Materials Letters, no. 2, 2020, doi: 10.1021/acsmaterialslett.0c00002.