High-Throughput Manufacturing of Antibacterial Nanofibers by Melt Coextrusion and Post-Processing Surface-Initiated Atom Transfer Radical Polymerization AITranslate

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DOI：https://doi.org/10.1021/acsapm.1c01264

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Polymeric nanofiber scaffolds are widely used for drug delivery, tissue engineering, and as advanced bandages. A high-throughput melt-processing method to fabricate polyester nanofibers was recently developed, as well as subsequent photochemical modification to generate functional fibers for use in tissue engineering and filtration. This work builds on these processes and details methods to develop antibacterial nanofiber mats. Melt coextrusion was used to fabricate poly(ε-caprolactone) (PCL) nanofibers. The isolated fibers could then be modified using grafting-from or grafting-to strategies to install antimicrobial polymers on their surfaces. The antimicrobial mats derived from the grating-from strategy demonstrated superior antimicrobial activity against Gram-positive and Gram-negative bacteria, while maintaining biocompatibility. The work developed herein provides a scalable method to fabricate advanced, functional, nonwoven mats that show potential for use as advanced bandages.