Amphiphilic Graft Copolymer of Polylysine-g-polytetrahydrofuran and Its Biological Properties AITranslate

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DOI：https://doi.org/10.1021/acsapm.2c00731

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The graft copolymer of poly-(N-ε-carbobenzyloxy-l-lysine)-g-poly(tetrahydrofuran) (PZLL-g-PTHF) could be successfully synthesized via the nucleophilic substitution reaction of PTHF+ living polymer chains with secondary amine side groups in the PZLL backbone. The amphiphilic graft copolymers of polylysine-g-poly(tetrahydrofuran) (PLL-g-PTHF) could be obtained by complete deprotection of the precursor of PZLL-g-PTHF. The obvious microphase separation was observed in both PLL-g-PTHF and PZLL-g-PTHF because of the incompatibility between the two kinds of segments. Their micromorphology is dependent on the chemical structure of backbones and the grafting number (GN) of branches. PZLL-g-PTHF is a hydrophobic graft copolymer and the water contact angles (WCAs) of copolymer surfaces decreased from 103 to 91° with the increase of GN from 5 to 21. Interestingly, PLL-g-PTHF is an amphiphilic graft copolymer and their WCAs increased from 52 to 90° with the increase of GN from 5 to 21. Both PZLL-g-PTHF and PLL-g-PTHF copolymers show good biocompatibility and anti-protein adsorption. The resulting PZLL-g-PTHF copolymers carrying a small amount of Ag nanoparticles, in situ generated from coinitiator AgClO4 for the synthesis of PTHF+ living chains, exhibit high killing efficiency (>95%) for both Escherichia coli and Staphylococcus aureus. PLL-g-PTHF/Ag nanocomposites show extremely high killing efficiency (>99%) against both S. aureus and E. coli for binary contribution from Ag nanoparticles and PLL. The antifouling and antibacterial graft copolymers would potentially have biological and medical applications.