Facile Syntheses of a Poly-2-phenylbenzobisthiazole-Based Theranostic Nanoplatform AITranslate

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DOI：https://doi.org/10.1021/acsapm.3c02073

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Photothermal therapy (PTT) is a therapeutic method emerging in recent years, and the photothermal conversion performance of the photothermal agent directly determines the effect of PTT. Poly-2-phenylbenzobisthiazole (PB) is a type of conjugated polymer with a simple synthesis method. It has good biocompatibility and degradability as well as excellent photothermal properties. However, the poor hydrophilicity of PB limits its application in biomaterials. In this work, a reversed-phase precipitation self-assembly method was used to prepare and obtain well-dispersed PB-based nanoparticles. PB and ferric chloride were first dissolved in N-methylpyrrolidone, after which the mixed solution was added dropwise to an aqueous solution of polyphenol and hyaluronic acids. The polyphenol–metal self-assembly network was complexed with PB molecular chains. The water-soluble nanoparticles PFGH prepared exhibited good photothermal properties and had great potential in the field of PTT.