Doxorubicin-Loaded Hybrid Micelles Based on Carboxyl-Terminated Hyperbranched Polyester Polyol AITranslate

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DOI：https://doi.org/10.1021/acsapm.1c01863

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The study of self-assembly processes in polymer solutions is the basis of a modern strategy for creating targeting systems for various substrates. In turn, the use of binary polymer/surfactant systems makes it possible to expand the range of polymers for creating drug delivery systems. This article describes the processes of formation of hybrid micelles based on carboxyl-terminal hyperbranched polyester polyol Boltorn H20─[BH20-COOH] and surfactant Triton X-100─[BH20-COOH/TX-100]. Using pH-metry, conductometry, dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), and scanning electron microscopy (SEM), it was shown that at pH = 6.5, a monodisperse [BH20-COOH] associate with a hydrodynamic diameter Dh = 79 ± 10 nm and hybrid micelles [BH20-COOH/TX-100] with Dh = 114.3 ± 6 nm are formed. Both types of supramolecular associates are able to effectively encapsulate the anticancer drug doxorubicin. The viability analysis of HeLa and MCF-7 cells was performed in the presence of doxorubicin-loaded [BH20-COOH] and hybrid micelles [BH20-COOH/TX-100] in vitro.