Microporous Spongy Scaffolds Based on Biodegradable Elastic Polyurethanes for the Migration and Growth of Host Cells AITranslate

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DOI：https://doi.org/10.1021/acsapm.2c00398

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The three-dimensional structure and the surface wettability of tissue engineering scaffolds are the crucial factors in the process of tissue regeneration. In this study, biodegradable poly(ester-ether-urethane)ureas (PEEUUs) were synthesized by employing polycaprolactone diol (PCL diol) and polyethylene glycol (PEG) with the settled molar ratios 100:0, 85:15, 65:35, and 50:50 as the primary monomer. Then, the synthesized PEEUUs were processed into a three-dimensional microporous spongy scaffold (3DMSS) through the thermally induced phase separation technology. The results showed that the content of PEG in the primary monomer has a significant impact on the microstructure, porosity, wettability, water absorption, biodegradability rate, and mechanical properties of the microporous spongy scaffold (MSS). Cell experiments in vitro proved that the addition of PEG in the molecular chain of PEEUUs significantly improves the ability of cell adhesion and proliferation of 3DMSS. All the results demonstrated the better cell migration effect of 3DMSS with PEG in injured tissue defect repair, indicating their great potential for facilitating rapid reconstruction of a specific tissue in clinic.