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A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery AITranslate

Sophia N. Economidou; Md. Jasim Uddin; Manuel J. Marques; Dennis Douroumis; Wan Ting Sow; Huaqiong Li; Andrew Reid; James F.C. Windmill; Adrian Podoleanu
University of Kent; BRAC University; University of Kent;CIPER Centre for Innovation and Process Engineering Research; University of Chinese Academy of Sciences; University of Chinese Academy of Sciences; University of Strathclyde; University of Strathclyde; University of Kent
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Publisher: Elsevier
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Abstract AITranslate

The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.

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DOI：https://doi.org/10.1016/j.addma.2020.101815

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Citation Information:

The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.

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GB/T 7714-2015 [1] Sophia N. Economidou, Md. Jasim Uddin, Manuel J. Marques, et al. Additive Manufacturing, 2021(38). DOI:10.1016/j.addma.2020.101815.
MLA [1] Sophia N. Economidou, et al., Additive Manufacturing, no. 38, 2021, https://doi.org/10.1016/j.addma.2020.101815.
APA [1] Sophia N. Economidou, Md. Jasim Uddin, Manuel J. Marques, Dennis Douroumis, Wan Ting Sow, Huaqiong Li, Andrew Reid, James F.C. Windmill, & Adrian Podoleanu. (2021). Additive Manufacturing(38). https://doi.org/10.1016/j.addma.2020.101815
IEEE [1] Sophia N. Economidou, Md. Jasim Uddin, Manuel J. Marques, Dennis Douroumis, Wan Ting Sow, Huaqiong Li, Andrew Reid, James F.C. Windmill, and Adrian Podoleanu, Additive Manufacturing, no. 38, 2021, doi: 10.1016/j.addma.2020.101815.