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Selective laser sintering (SLS) technique for pharmaceutical applications—Development of high dose controlled release printlets AITranslate

Piotr Kulinowski; Piotr Malczewski; Edyta Pesta; Marta Łaszcz; Aleksander Mendyk; Sebastian Polak; Przemysław Dorożyński
Pedagogical University of Kraków; Pedagogical University of Kraków; Łukasiewicz Research Network – Industrial Chemistry Institute; Łukasiewicz Research Network – Industrial Chemistry Institute; Jagiellonian University Medical College; Jagiellonian University Medical College; Medical University of Warsaw
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Publisher: Elsevier
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Abstract AITranslate

The paper presents the unique approach to 3D printing by Selective Laser Sintering of high dose controlled release pharmaceutical dosage form, which contains almost exclusively drug substance - just crystalline paracetamol as a model drug substance and small amount of dye were used. Comprehensive printlet characterization, that included pore space analysis, drug release and subsequent dissolution modeling as well as exploratory analysis, revealed various degrees of freedom for tuning its functional properties i.e. dissolution performance. Two degrees of freedom were found substantial for the proposed approach: (1) the macro structure shaping in terms of active surface to volume ratio; (2) microstructure shaping in terms of pore space structure. The latter was found to have a great potential and can be modified by the manufacturing parameters, e.g. hatch spacing. The simplicity of the preparation and flexibility to control the dissolution performance of the pharmaceutical dosage are the advantages of the proposed approach. Graphical Download : Download high-res image (336KB) Download : Download full-size image

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DOI：https://doi.org/10.1016/j.addma.2020.101761

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Citation Information:

The paper presents the unique approach to 3D printing by Selective Laser Sintering of high dose controlled release pharmaceutical dosage form, which contains almost exclusively drug substance - just crystalline paracetamol as a model drug substance and small amount of dye were used. Comprehensive printlet characterization, that included pore space analysis, drug release and subsequent dissolution modeling as well as exploratory analysis, revealed various degrees of freedom for tuning its functional properties i.e. dissolution performance. Two degrees of freedom were found substantial for the proposed approach: (1) the macro structure shaping in terms of active surface to volume ratio; (2) microstructure shaping in terms of pore space structure. The latter was found to have a great potential and can be modified by the manufacturing parameters, e.g. hatch spacing. The simplicity of the preparation and flexibility to control the dissolution performance of the pharmaceutical dosage are the advantages of the proposed approach. Graphical Download : Download high-res image (336KB) Download : Download full-size image

quote

GB/T 7714-2015 [1] Piotr Kulinowski, Piotr Malczewski, Edyta Pesta, et al. Additive Manufacturing, 2021(38). DOI:10.1016/j.addma.2020.101761.
MLA [1] Piotr Kulinowski, et al., Additive Manufacturing, no. 38, 2021, https://doi.org/10.1016/j.addma.2020.101761.
APA [1] Piotr Kulinowski, Piotr Malczewski, Edyta Pesta, Marta Łaszcz, Aleksander Mendyk, Sebastian Polak, & Przemysław Dorożyński. (2021). Additive Manufacturing(38). https://doi.org/10.1016/j.addma.2020.101761
IEEE [1] Piotr Kulinowski, Piotr Malczewski, Edyta Pesta, Marta Łaszcz, Aleksander Mendyk, Sebastian Polak, and Przemysław Dorożyński, Additive Manufacturing, no. 38, 2021, doi: 10.1016/j.addma.2020.101761.