Polymeric Particulates of Controlled Rigidity for Biomedical Applications AITranslate

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DOI：https://doi.org/10.1021/acsapm.1c00157

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The mechanical stiffness of polymer particles is an important parameter that influences particle circulation in the blood and governs cell–particle adhesion, cellular uptake, and biodistribution. This Review highlights the main approaches to produce micro and nanosized polymeric particulates with controlled mechanical responses and their applications in the biomedical field. We discuss how varying mechanical properties of polymeric particles can affect particle interactions with various types of cancer and immune cells, along with particle behavior in the flow. We also analyze the possibilities of regulating particle rigidity by controlling particle shape, a relatively unexplored research area. The main measurement methods to test the mechanical responses of polymeric particulates are also reviewed. Finally, we summarize recent developments toward controlling the mechanical responses of polymeric particulates relevant to biomedical applications and highlight important perspective directions that can advance fundamental and applied research in this area.