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Photoactive Oligomer with an Acceptor–Donor–Acceptor-Conjugated Structure for Single Near-Infrared Light-Triggered Photothermal/Photodynamic Synergistic Therapy of Tumors AITranslate

Linlin Zhao; Meijia Chang; Zheng He; Yunying Zhao; Jing Wang; Yan Lu
Tianjin University of Technology; Luoyang Institute of Science and Technology; Tianjin University of Technology; Tianjin University of Technology; Tianjin University of Technology; Tianjin University of Technology
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Publisher: ACS
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Abstract AITranslate

Phototherapy is attracting increasing attention as a noninvasive, safe, and effective therapeutic modality for tumors. Especially, it is expected to achieve better therapeutic efficacy, fewer side effect, and deeper tissue penetration by the combination of photothermal (PTT) and photodynamic (PDT) under single near-infrared (NIR) light irradiation. For this purpose, herein, we develop a photoactive acceptor (A)–donor (D)–acceptor (A)-type conjugated oligomer (UF-TTOEH-2Cl). A NIR light-responsive nanoplatform (UTNPs) was fabricated based on UF-TTOEH-2Cl, and a folic acid-functionalized amphiphilic block copolymer (FA-PEG-PBLA10) was prepared as the polymer matrix through a nanoprecipitation method, which showed a high photothermal conversion efficiency (42%) and singlet oxygen (1O2) quantum yield (ΦΔ = 17.2%) under 880 nm laser irradiation. Furthermore, efficient UTNPs-based PDT/PTT synergistic therapy of tumors was demonstrated utilizing HeLa and SiHa cells as the models in vitro.

KeyWords AITranslate

photoactive materials phototherapy acceptor−donor−acceptor structure NIR light synergistic therapy
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Basic Information:

DOI：https://doi.org/10.1021/acsapm.2c02016

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Citation Information:

Phototherapy is attracting increasing attention as a noninvasive, safe, and effective therapeutic modality for tumors. Especially, it is expected to achieve better therapeutic efficacy, fewer side effect, and deeper tissue penetration by the combination of photothermal (PTT) and photodynamic (PDT) under single near-infrared (NIR) light irradiation. For this purpose, herein, we develop a photoactive acceptor (A)–donor (D)–acceptor (A)-type conjugated oligomer (UF-TTOEH-2Cl). A NIR light-responsive nanoplatform (UTNPs) was fabricated based on UF-TTOEH-2Cl, and a folic acid-functionalized amphiphilic block copolymer (FA-PEG-PBLA10) was prepared as the polymer matrix through a nanoprecipitation method, which showed a high photothermal conversion efficiency (42%) and singlet oxygen (1O2) quantum yield (ΦΔ = 17.2%) under 880 nm laser irradiation. Furthermore, efficient UTNPs-based PDT/PTT synergistic therapy of tumors was demonstrated utilizing HeLa and SiHa cells as the models in vitro.

quote

GB/T 7714-2015 [1] Linlin Zhao, Meijia Chang, Zheng He, et al. ACS Applied Polymer Materials, 2023(5). DOI:10.1021/acsapm.2c02016.
MLA [1] Linlin Zhao, et al., ACS Applied Polymer Materials, no. 5, 2023, https://doi.org/10.1021/acsapm.2c02016.
APA [1] Linlin Zhao, Meijia Chang, Zheng He, Yunying Zhao, Jing Wang, & Yan Lu. (2023). ACS Applied Polymer Materials(5). https://doi.org/10.1021/acsapm.2c02016
IEEE [1] Linlin Zhao, Meijia Chang, Zheng He, Yunying Zhao, Jing Wang, and Yan Lu, ACS Applied Polymer Materials, no. 5, 2023, doi: 10.1021/acsapm.2c02016. keywords: {photoactive materials;phototherapy;acceptor−donor−acceptor structure;NIR light;synergistic therapy}