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Photodynamic Bubble-Generating Microneedles for Enhanced Transdermal Cancer Therapy AITranslate

Xiaoyu Ning; Si Chen; Yating Yang; Jangsun Hwang; Christian Wiraja; Chi Zhang; Wei Liu; Linbo Liu; Chenjie Xu
Nanyang Technological University; Nanyang Technological University; Shanghai Jiao Tong University School of Medicine; Nanyang Technological University; Nanyang Technological University; Nanyang Technological University; Shanghai Jiao Tong University School of Medicine; Nanyang Technological University; City University of Hong Kong
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Publisher: ACS
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Abstract AITranslate

Active bubble-generating microneedles (MNs) upon skin interstitial fluid (ISF) contact facilitate deeper and more efficient delivery of intradermal therapeutics. However, bubble-generating MN platforms are sensitive to moisture, which limits their variety to load various functional drugs. This article presents a frozen immersion method that facilitates both hydrophobic and hydrophilic drug loading onto bubble-generating MNs without compromising both drug and MN properties. The formed bubbles upon ISF contact induce distinct vortex flow that produces a propulsion force to enhance drug transportation. The efficiency of transdermal drug delivery is further enhanced by sonophoresis. The drug delivery efficiency of this platform is first evaluated ex vivo using fresh mouse skins and human keloid tissues. Later, in the tumor-bearing mouse model, the platform enhances the skin penetration of photosensitizers (i.e., methylene blue) and correspondingly improves the efficacy of photodynamic therapy.

KeyWords AITranslate

bubblegenerating microneedles frozen immersion transdermal drug delivery sonophoresis photodynamic therapy
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Basic Information:

DOI：https://doi.org/10.1021/acsapm.1c01219

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Citation Information:

Active bubble-generating microneedles (MNs) upon skin interstitial fluid (ISF) contact facilitate deeper and more efficient delivery of intradermal therapeutics. However, bubble-generating MN platforms are sensitive to moisture, which limits their variety to load various functional drugs. This article presents a frozen immersion method that facilitates both hydrophobic and hydrophilic drug loading onto bubble-generating MNs without compromising both drug and MN properties. The formed bubbles upon ISF contact induce distinct vortex flow that produces a propulsion force to enhance drug transportation. The efficiency of transdermal drug delivery is further enhanced by sonophoresis. The drug delivery efficiency of this platform is first evaluated ex vivo using fresh mouse skins and human keloid tissues. Later, in the tumor-bearing mouse model, the platform enhances the skin penetration of photosensitizers (i.e., methylene blue) and correspondingly improves the efficacy of photodynamic therapy.

quote

GB/T 7714-2015 [1] Xiaoyu Ning, Si Chen, Yating Yang, et al. ACS Applied Polymer Materials, 2021(3). DOI:10.1021/acsapm.1c01219.
MLA [1] Xiaoyu Ning, et al., ACS Applied Polymer Materials, no. 3, 2021, https://doi.org/10.1021/acsapm.1c01219.
APA [1] Xiaoyu Ning, Si Chen, Yating Yang, Jangsun Hwang, Christian Wiraja, Chi Zhang, Wei Liu, Linbo Liu, & Chenjie Xu. (2021). ACS Applied Polymer Materials(3). https://doi.org/10.1021/acsapm.1c01219
IEEE [1] Xiaoyu Ning, Si Chen, Yating Yang, Jangsun Hwang, Christian Wiraja, Chi Zhang, Wei Liu, Linbo Liu, and Chenjie Xu, ACS Applied Polymer Materials, no. 3, 2021, doi: 10.1021/acsapm.1c01219. keywords: {bubblegenerating microneedles;frozen immersion;transdermal drug delivery;sonophoresis;photodynamic therapy}