Polyamidoamine Dendrimer-Modified Near Infrared-II Fluorescent Conjugated Polymer Brush for Photodynamic/Gas Therapy AITranslate

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DOI：https://doi.org/10.1021/acsapm.2c00638

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The short lifespan of reactive oxygen species (ROS) and hypoxia nature of solid tumor severely impede the therapeutic efficacy of photodynamic therapy (PDT). To overcome this challenge, the light-triggered PDT/carbon monoxide (CO) gas therapy synergistic systems have received considerable attention. However, the development of single organic material-based multifunctional nanoplatforms for NIR-II fluorescence imaging (NIR-II FI) and synergistic PDT/CO gas therapy remains a challenge. Herein, a multifunctional NIR-II FI/PDT/CO gas therapy conjugated polymer brush (PBF-g-CO/PEG) was established by covalent conjugation of CO donors (CORM-401) onto a water-soluble polyamidoamine dendrimer-modified NIR-II fluorophore (PBF-AM3). The electron-rich polyamidoamine dendrimer-modified PBF-AM3 could be irradiated with 660 nm light to efficiently produce ROS and trigger CO release from CORM-401 inducing cancer cell apoptosis. Importantly, under the guidance of NIR-II FI, the PBF-g-CO/PEG polymer demonstrates superior in vivo anticancer efficacy by the combination of photodynamic and CO gas therapy. The remarkable anticancer efficacy and admirable biocompatibility endow PBF-g-CO/PEG with great potential for precision cancer therapy.