Cell-Specific Adhesion Interfaces by Electrochemical Copolymerization of Arg-Gly-Asp-Tyr and 4-(2-(2-Ethoxyethoxy) Ethoxy) Phenol AITranslate

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DOI：https://doi.org/10.1021/acsapm.1c00134

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Arg-Gly-Asp (RGD), a classical polypeptide, has been widely used in cell specific recognition. RGDY (Arg-Gly-Asp-Tyr) consists of the RGD sequence and tyrosine. Herein, a functional coating with cell-specific adhesion (with human umbilical vein endothelial cells as the model) and antiprotein adhesion (with bovine serum albumin as the model) properties was green synthesized by electrochemical copolymerization of RGDY and 4-(2-(2-ethoxyethoxy) ethoxy) phenol. Fourier transform infrared spectroscopy and scanning electron microscopy were used to characterize the functional groups and morphology of the copolymer, respectively. Cyclic voltammetry and electrochemical impedance spectroscopy were used to study the electrochemical performance of the modified electrode. A quartz crystal microbalance was used to reflect the modification and antiprotein adhesion process of the copolymer and the following process of cell-specific adhesion. The cell adsorption and antiprotein adhesion properties of the modified electrode are significantly improved. Herein, a green method was used to prepare a stable coating with cell-specific adhesion and antiprotein adhesion by electrochemical copolymerization of typical cell-specific recognition peptides and oligopoly(ethylene glycol) derivatives. It has a potential application value in the modification of biomaterials, the preparation of cell-specific sensors, and the development of special biological carriers.