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Biocompatible Magnetic Conjugated Polymer Nanoparticles for Optical and Lifetime Imaging Applications in the First Biological Window AITranslate

Struan Bourke; Federico Donà; Yurema Teijeiro Gonzalez; Basma Qazi Chaudhry; Maryna Panamarova; Eirinn Mackay; Peter S. Zammit; Lea Ann Dailey; Ulrike S. Eggert; Klaus Suhling; Mark A. Green;
King′s College London; King’s College London; King′s College London; King′s College London; King’s College London; University College London; King’s College London; University of Vienna; King’s College London; King′s College London; King′s College London
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Publisher: ACS
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Abstract AITranslate

Conjugated polymers are organic semiconductors that can be used for fluorescence microscopy of living specimens. Here, we report the encapsulation of the bright-red-emitting conjugated polymer, poly[{9,9-dihexyl-2,7-bis(1-cyanovinylene)fluorenylene}-alt-co-{2,5-bis(N,N′-diphenylamino)-1,4-phenylene}] (CN-FO-DPD), and superparamagnetic iron oxide nanoparticles (SPIONs) within poly(styrene-co-maleic anhydride) (PSMA) micelles. The resulting particles exhibited an emission peak at 657 nm, a fluorescence quantum yield of 21%, an average diameter of 65 nm, and a ζ potential of −30 mV. They are taken up by cells, and we describe their use in fluorescence microscopy of living Hela cells and zebrafish embryos and their associated cytotoxicity in HEK, HeLa, and HCE cells.

KeyWords AITranslate

conjugated polymers nanoparticles biological imaging cytotoxicity studies fluorescence lifetime studies zebrafish
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DOI：https://doi.org/10.1021/acsapm.2c01153

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Citation Information:

Conjugated polymers are organic semiconductors that can be used for fluorescence microscopy of living specimens. Here, we report the encapsulation of the bright-red-emitting conjugated polymer, poly[{9,9-dihexyl-2,7-bis(1-cyanovinylene)fluorenylene}-alt-co-{2,5-bis(N,N′-diphenylamino)-1,4-phenylene}] (CN-FO-DPD), and superparamagnetic iron oxide nanoparticles (SPIONs) within poly(styrene-co-maleic anhydride) (PSMA) micelles. The resulting particles exhibited an emission peak at 657 nm, a fluorescence quantum yield of 21%, an average diameter of 65 nm, and a ζ potential of −30 mV. They are taken up by cells, and we describe their use in fluorescence microscopy of living Hela cells and zebrafish embryos and their associated cytotoxicity in HEK, HeLa, and HCE cells.

quote

GB/T 7714-2015 [1] Struan Bourke, Federico Donà, Yurema Teijeiro Gonzalez, et al. ACS Applied Polymer Materials, 2022(4). DOI:10.1021/acsapm.2c01153.
MLA [1] Struan Bourke, et al., ACS Applied Polymer Materials, no. 4, 2022, https://doi.org/10.1021/acsapm.2c01153.
APA [1] Struan Bourke, Federico Donà, Yurema Teijeiro Gonzalez, Basma Qazi Chaudhry, Maryna Panamarova, Eirinn Mackay, Peter S. Zammit, Lea Ann Dailey, Ulrike S. Eggert, Klaus Suhling, & Mark A. Green. (2022). ACS Applied Polymer Materials(4). https://doi.org/10.1021/acsapm.2c01153
IEEE [1] Struan Bourke, Federico Donà, Yurema Teijeiro Gonzalez, Basma Qazi Chaudhry, Maryna Panamarova, Eirinn Mackay, Peter S. Zammit, Lea Ann Dailey, Ulrike S. Eggert, Klaus Suhling, and Mark A. Green, ACS Applied Polymer Materials, no. 4, 2022, doi: 10.1021/acsapm.2c01153. keywords: {conjugated polymers;nanoparticles;biological imaging;cytotoxicity studies;fluorescence lifetime studies;zebrafish}