Tissue engineering of skeletal muscle, tendons and nerves: A review of manufacturing strategies to meet structural and functional requirements AITranslate

Basic Information:

DOI：https://doi.org/10.1016/j.apmt.2023.101737

Chinese Library Classification Number:

Citation Information:

Highlights • Current strategies for engineering hierarchically organized tissues are described and discussed, including solution electrospinning and additive manufacturing. • The mechanical and biological properties of tissues that should form the basis for efficient three-dimensional design are presented. • Different factors in the fabrication process (material selection, biological model, and processing technique) that influence the mechanical and biological properties of the engineered tissues are discussed. • An analysis of the strengths and limitations of the different techniques is described, which can serve as a reference for selecting the appropriate method or combination of methods. • Critical aspects relevant to future research strategies are summarized. Additive manufacturing technologies have become at the forefront in tissue engineering, enabling the fabrication of complex tissues with intricate geometries that were not feasible using conventional manufacturing techniques. Due to the rapid progress in this field, it has become difficult not only to choose the most appropriate method, but also the optimal material, biological model (i.e., cells and bioactive compounds), and processing technique to fulfill the macro- and microstructural architecture and functions of biological tissues. The aim of this review is to describe recent advances in tissue engineering fabrication methods, from established electrospinning to emerging additive manufacturing technologies, with particular emphasis on tissues that exhibit hierarchically organized anisotropic architecture (skeletal muscle, tendons, and peripheral nerves). One of the current challenges is that the designs are usually dictated by the constraints imposed by the methods, rather than by criteria based on mechanical and biological requirements. Therefore, the review focuses on describing how the anatomical structure and function of muscles, tendons, and nerves should serve as the basis for an efficient three-dimensional design that considers both micro and macro aspects of the tissue. In addition, the individual factors that influence the fabrication strategy are discussed and related to the mechanical and biological properties of the three tissue types. The review highlights the advantages and limitations of each fabrication strategy and provides an overview of critical aspects relevant to future research strategies in this area. Graphical abstract Download : Download high-res image (181KB) Download : Download full-size image