Synthesis, Characterization, and Processing of Highly Bioadhesive Polyurethane Urea as a Microfibrous Scaffold Inspired by Mussels AITranslate

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DOI：https://doi.org/10.1021/acsapm.3c01578

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The need to obtain solid adhesive scaffolds that can be processed to create friendly microenvironments, direct cellular behaviors, and tissue regeneration is growing. A facile method was used to incorporate a mussel-inspired adhesive moiety, dopamine, into segmented polyurethanes based on polycaprolactone–polyethylene glycol–polycaprolactone (PCL–PEG–PCL) copolymers. Dopamine was chemically bonded to lysine and used as a chain extender to obtain a solid biodegradable elastomer capable of strongly adhering to different materials after melting occurs. Lysine alone was used as a chain extender to produce a similar polyurethane control group. The low melting point (55 °C) opens multiple possible applications for this polyurethane. A complete chemical–physical characterization was performed, and adhesion strength was evaluated in a lap shear configuration. The interaction with a high-energy surface like glass and aluminum at room temperature was remarkable (respectively 2.8 and 2.6 MPa). The adhesion was also evaluated with porcine skin underwater at 37 °C, resulting in 30 kPa. Over a period of 6 months, the material undergoes slow hydrolytic degradation. Nevertheless, the material and its degradation products were not cytotoxic. The polymer was then processed with melt extrusion three-dimensional (3D) printing to obtain oriented microfibers, producing different scaffolds.