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Photo-responsive Self-Reducible Polymers: Overcoming the Spatiotemporal Barriers for Hypersensitivity AITranslate

Chuang Weng; Haodong Chen; Taoran Xu; Zifen Li; Xinfu Liu; Mingming Ding; Qin Zhang; Hong Tan; Qiang Fu;
Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University
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Publisher: ACS
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Abstract AITranslate

To overcome the spatiotemporal barriers to conventional stimuli-responsive polymeric materials, we report a photo-responsive self-reducible polymer with a built-in photo-locked stimulus precursor derived from dithiothreitol. The smart polymer could hierarchically self-assemble into a layered vesicular structure in an aqueous solution, and undergo a self-cleavage of l-cystine residues in the backbone, in response to reducing moieties uncaged by ultraviolet light in the side chains. The photo-generation of stimulus in situ can potentially overcome the steric hindrance and temporal limitation, leading to a site-specific and ultrafast release of payloads for effective delivery of therapeutics. Our work provides a new approach to the development of smart responsive biodegradable polymers.

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DOI：https://doi.org/10.1021/acsmaterialslett.0c00070

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Citation Information:

To overcome the spatiotemporal barriers to conventional stimuli-responsive polymeric materials, we report a photo-responsive self-reducible polymer with a built-in photo-locked stimulus precursor derived from dithiothreitol. The smart polymer could hierarchically self-assemble into a layered vesicular structure in an aqueous solution, and undergo a self-cleavage of l-cystine residues in the backbone, in response to reducing moieties uncaged by ultraviolet light in the side chains. The photo-generation of stimulus in situ can potentially overcome the steric hindrance and temporal limitation, leading to a site-specific and ultrafast release of payloads for effective delivery of therapeutics. Our work provides a new approach to the development of smart responsive biodegradable polymers.

quote

GB/T 7714-2015 [1] Chuang Weng, Haodong Chen, Taoran Xu, et al. ACS Materials Letters, 2020(2). DOI:10.1021/acsmaterialslett.0c00070.
MLA [1] Chuang Weng, et al., ACS Materials Letters, no. 2, 2020, https://doi.org/10.1021/acsmaterialslett.0c00070.
APA [1] Chuang Weng, Haodong Chen, Taoran Xu, Zifen Li, Xinfu Liu, Mingming Ding, Qin Zhang, Hong Tan, & Qiang Fu. (2020). ACS Materials Letters(2). https://doi.org/10.1021/acsmaterialslett.0c00070
IEEE [1] Chuang Weng, Haodong Chen, Taoran Xu, Zifen Li, Xinfu Liu, Mingming Ding, Qin Zhang, Hong Tan, and Qiang Fu, ACS Materials Letters, no. 2, 2020, doi: 10.1021/acsmaterialslett.0c00070.