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Magnetically powered helical hydrogel motor for macrophage delivery AITranslate

Juanyan Wu; Lu Liu; Bin Chen; Juanfeng Ou; Fei Wang; Junbin Gao; Jiamiao Jiang; Yicheng Ye; Shuanghu Wang; Fei Tong; Hao Tian; Daniela A. Wilson; Yingfeng Tu; Fei Peng;
Southern Medical University; Sun Yat-Sen University; Southern Medical University; Southern Medical University; Southern Medical University; Southern Medical University; Southern Medical University; Southern Medical University; Southern Medical University; Southern Medical University; Southern Medical University; Radboud University; Southern Medical University; Sun Yat-Sen University
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Publisher: Elsevier
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Abstract AITranslate

Immune cell therapy, holds immense promise for immune regulation and major disease combating. The precise transport and controlled release of immune cells to the target diseased site is a promising yet challenging topic. Herein, we proposed that melamine-crosslinked polyvinyl alcohol (PVA)/iron oxide hydrogel motor platform with sufficient live M1-like macrophage (M1Φ) cells cultured inside, can represent a novel approach for active and targeted immune cell therapy. The M1 macrophages-loaded motors could precisely navigate to the designated site using a low-strength rotating magnetic field and actively release cells with an external ultrasound trigger. The system indicates excellent potential for precise immune cell therapy. Graphical abstract Download : Download high-res image (124KB) Download : Download full-size image

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DOI：https://doi.org/10.1016/j.apmt.2021.101197

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Citation Information:

Immune cell therapy, holds immense promise for immune regulation and major disease combating. The precise transport and controlled release of immune cells to the target diseased site is a promising yet challenging topic. Herein, we proposed that melamine-crosslinked polyvinyl alcohol (PVA)/iron oxide hydrogel motor platform with sufficient live M1-like macrophage (M1Φ) cells cultured inside, can represent a novel approach for active and targeted immune cell therapy. The M1 macrophages-loaded motors could precisely navigate to the designated site using a low-strength rotating magnetic field and actively release cells with an external ultrasound trigger. The system indicates excellent potential for precise immune cell therapy. Graphical abstract Download : Download high-res image (124KB) Download : Download full-size image

quote

GB/T 7714-2015 [1] Juanyan Wu, Lu Liu, Bin Chen, et al. Applied Materials Today, 2021(25). DOI:10.1016/j.apmt.2021.101197.
MLA [1] Juanyan Wu, et al., Applied Materials Today, no. 25, 2021, https://doi.org/10.1016/j.apmt.2021.101197.
APA [1] Juanyan Wu, Lu Liu, Bin Chen, Juanfeng Ou, Fei Wang, Junbin Gao, Jiamiao Jiang, Yicheng Ye, Shuanghu Wang, Fei Tong, Hao Tian, Daniela A. Wilson, Yingfeng Tu, & Fei Peng. (2021). Applied Materials Today(25). https://doi.org/10.1016/j.apmt.2021.101197
IEEE [1] Juanyan Wu, Lu Liu, Bin Chen, Juanfeng Ou, Fei Wang, Junbin Gao, Jiamiao Jiang, Yicheng Ye, Shuanghu Wang, Fei Tong, Hao Tian, Daniela A. Wilson, Yingfeng Tu, and Fei Peng, Applied Materials Today, no. 25, 2021, doi: 10.1016/j.apmt.2021.101197.