Alkaline Amino Acid Alternating Copolymers with Potent Antibacterial Properties for the Treatment of Periodontitis AITranslate

Basic Information:

DOI：https://doi.org/10.1021/acsapm.3c00309

Chinese Library Classification Number:

Citation Information:

Although antibacterial peptides with excellent properties emerge endlessly, the antibacterial peptides with alternating structures have not attracted much attention. In this work, three amino acid alternating copolymers (Orn-Ser, Orn-Gly, and Orn-Val) with similar molecular weights but different hydrophilicity were constructed for the study of antibacterial properties through the solid-phase peptide synthesis (SPPS) method. We found that these three amino acid alternating copolymers showed excellent biocompatibility and broad spectrum antibacterial activity. Nevertheless, they showed slightly different properties due to differences in hydrophilicity and cationic density, for instance, better biocompatibility of Orn-Ser, stronger antibacterial property of Orn-Gly, and a higher selectivity index of Orn-Val. In a rat periodontitis model, Orn-Gly and Orn-Val exhibited remarkable anti-infective performance and significant therapeutic effects. This work is expected to play an important role in the treatment of periodontitis and the rational design of antimicrobial peptides for different applications.