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Construction of Curcumin-Loaded Hydrogels for Treatment of Traumatic Brain Injury AITranslate

Linna Sun; Qinghe Li; Yuting Guo; Xiaofeng Wu; Mingxing Han; Luzhong Zhang; Peiyuan Wang;
Yantai Affiliated Hospital of Binzhou Medical University; Yantai Affiliated Hospital of Binzhou Medical University; Yantai Affiliated Hospital of Binzhou Medical University; Yantai Affiliated Hospital of Binzhou Medical University; Yantai Affiliated Hospital of Binzhou Medical University; Nantong University; Yantai Affiliated Hospital of Binzhou Medical University
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Publisher: ACS
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Abstract AITranslate

Traumatic brain injury (TBI) is a common clinical disease, and the current hyperbaric oxygen and hypothermia therapy are suboptimal. Traumatic brain injuries were accompanied by acute inflammatory reactions, brain edema, neuron damage, and the destruction of blood–brain barrier. Herein, curcumin-loaded lysine/poly(ethylene glycol) diacrylate (PEGDA) hydrogels were constructed via Michael addition for traumatic brain injury treatments. The curcumin-loaded lysine/PEGDA hydrogels were injected into brain injury defect sites with complex anatomical and irregular structures. The real-time therapeutic effects of the curcumin-loaded hydrogels were evaluated by magnetic resonance imaging (MRI). Curcumin-loaded hydrogels can inhibit the inflammatory reaction and promote nerve repair. The curcumin-loaded hydrogel could provide a promising strategy for traumatic brain injury treatments.

KeyWords AITranslate

traumatic brain injury hydrogel curcumin nerve regeneration magnetic resonance imaging compatibility
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Basic Information:

DOI：https://doi.org/10.1021/acsapm.3c00065

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Citation Information:

Traumatic brain injury (TBI) is a common clinical disease, and the current hyperbaric oxygen and hypothermia therapy are suboptimal. Traumatic brain injuries were accompanied by acute inflammatory reactions, brain edema, neuron damage, and the destruction of blood–brain barrier. Herein, curcumin-loaded lysine/poly(ethylene glycol) diacrylate (PEGDA) hydrogels were constructed via Michael addition for traumatic brain injury treatments. The curcumin-loaded lysine/PEGDA hydrogels were injected into brain injury defect sites with complex anatomical and irregular structures. The real-time therapeutic effects of the curcumin-loaded hydrogels were evaluated by magnetic resonance imaging (MRI). Curcumin-loaded hydrogels can inhibit the inflammatory reaction and promote nerve repair. The curcumin-loaded hydrogel could provide a promising strategy for traumatic brain injury treatments.

quote

GB/T 7714-2015 [1] Linna Sun, Qinghe Li, Yuting Guo, et al. ACS Applied Polymer Materials, 2023(5). DOI:10.1021/acsapm.3c00065.
MLA [1] Linna Sun, et al., ACS Applied Polymer Materials, no. 5, 2023, https://doi.org/10.1021/acsapm.3c00065.
APA [1] Linna Sun, Qinghe Li, Yuting Guo, Xiaofeng Wu, Mingxing Han, Luzhong Zhang, & Peiyuan Wang. (2023). ACS Applied Polymer Materials(5). https://doi.org/10.1021/acsapm.3c00065
IEEE [1] Linna Sun, Qinghe Li, Yuting Guo, Xiaofeng Wu, Mingxing Han, Luzhong Zhang, and Peiyuan Wang, ACS Applied Polymer Materials, no. 5, 2023, doi: 10.1021/acsapm.3c00065. keywords: {traumatic brain injury;hydrogel;curcumin;nerve regeneration;magnetic resonance imaging;compatibility}